Calculate eGFR by the Full age spectrum (FAS) creatinine-cystatin-based equation

Usage

egfr.fas.cr_cys(
  creatinine,
  cystatin,
  age,
  sex,
  alpha = 0.5,
  creatinine_units = "micromol/l",
  cystatin_units = "mg/L",
  equation_type = "precise",
  label_sex_male = c("Male", 1),
  label_sex_female = c("Female", 0),
  max_age = 100
)

Arguments

creatinine: Numeric vector. Serum creatinine, could be expressed in "micromol/L", "mmol/L" or "mg/dL". Units of measurement should be defined in variable creatinine_units (if not defined explicitly by user, the default value is "micromol/L").
cystatin: Numeric vector. Serum cystatin, could be expressed in "mg/L" or "nanomol/L". Units of measurement should be defined in variable cystatin_units (if not defined explicitly by user, the default value is "mg/L").
age: Numeric vector. Age, in years.
sex: Vector. The value of variable refers to the parameters label_sex_male and label_sex_female.
alpha: Numeric vector. Alpha coefficient for the combined creatinine-cystatin equation. By default is equal to 0.5.
creatinine_units: Character string. Units in which serum creatinne is expressed. Could be one of the following: "micromol/L", "mmol/L" or "mg/dL".
cystatin_units: Character string. Units in which serum cystatin is expressed. Could be one of the following: "mg/L" or "nanomol/L"
equation_type: Character string. Whether to use "precise" or "simplified" equation.
label_sex_male: List. Label(s) for definition(s) of male sex.
label_sex_female: List. Label(s) for definition(s) of female sex.
max_age: Numeric. Maximal age suitable for the equation application, in years. By default is 100 years, but change this value in case you would like to apply equation to older persons.

Value

numeric eGFR expressed in ml/min/1.73m².

Details

Calculate estimated glomerular filtration rate (eGFR) by the Full age spectrum (FAS) creatinine-cystatin-based equation.

Reference to the equation: Pottel H, Delanaye P, Schaeffner E et al. Estimating glomerular filtration rate for the full age spectrum from serum creatinine and cystatin C. Nephrol Dial Transplant 2017; 32:497–507 doi:10.1093/ndt/gfw425.

Citation: Bikbov B. kidney.epi: Kidney-Related Functions for Clinical and Epidemiological Research. Scientific-Tools.Org, https://Scientific-Tools.Org. DOI: 10.32614/CRAN.package.kidney.epi

Author

Programming: Boris Bikbov https://www.linkedin.com/in/boris-bikbov.

Examples

# for a single patient
egfr.fas.cr_cys (creatinine = 1.4, cystatin = 0.8, age = 60,
   sex = "Male", creatinine_units = "mg/dl")
#> [1] 66.82
# for a dataset - see vignettes for details
# egfr.fas.cr_cys (creatinine = dta$scr, cystatin = dta$cys,
#  age = dta$age, sex = dta$sex, creatinine_units = "mg/dl")